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TITLE:
Patients with premenstrual syndrome have reduced
sensitivity to midazolam compared to control subjects.
AUTHOR:
Sundstrom I; Nyberg S; Backstrom T
AUTHOR AFFILIATION:
Department of Obstetrics and Gynecology,
University Hospital of Ume~a, Sweden.
SOURCE:
Neuropsychopharmacology 1997 Dec;17(6):370-81
NLM CIT. ID:
98059814
ABSTRACT:
Premenstrual syndrome (PMS) depends on gonadal
hormones produced by the corpus luteum. Given the facilitory actions on GABAergic
inhibitory neurotransmission exerted by certain progesterone metabolites, further studies
on the GABAA receptor system in premenstrual syndrome are warranted. This study evaluated
the benzodiazepine sensitivity in PMS patients and control subjects, using saccadic eye
velocity (SEV) and visual analogue ratings of sedation as dependent measures. PMS patients
displayed a significantly reduced SEV responsiveness to benzodiazepines compared to
control subjects in the follicular phase, whereas there was no difference between groups
in the luteal phase. In the luteal phase, the sedation response to benzodiazepines was
significantly reduced in PMS patients compared to control subjects. There was also an
influence of PMS symptom severity on these measures, as high-severity PMS patients
displayed blunted SEV and sedation responses to benzodiazepines compared to low-severity
patients. These results indicate that PMS patients have a reduced functional sensitivity
at the GABAA/benzodiazepine receptor complex throughout the menstrual cycle.
Adult
Comparative Study
Estradiol/BLOOD
Female
Human
Menstrual Cycle/BLOOD/PSYCHOLOGY
Middle Age
Pilot Projects
Progesterone/BLOOD
Support, Non-U.S. Gov't
When my office
lease expired at the end of 2004, I decided to turn it into a
"sabbatical" from my private practice. Many years ago, in my
grandfather's 89th year of life, he told me, "John, it is important
to smell the roses while you can still smell them." His life
gave living a very good reputation. It is also true that the
pursuit of that philosophy required my grandfather to to re-open his
assay office/ore market in Wickenburg, Arizona as a 75-year-old because
he had run a little short of retirement money. Thus, if blessed with his
luck and health, I'll be back.. --jjh
