National Library of Medicine: IGM
Full Record Screen
TITLE:
Daily repetitive transcranial magnetic
stimulation (rTMS) improves mood in depression.
AUTHOR:
George MS; Wassermann EM; Williams WA; Callahan
A; Ketter TA; Basser P; Hallett M; Post RM
AUTHOR AFFILIATION:
Biological Psychiatry Branch, National Institute
of Mental Health, Charleston, SC, USA.
SOURCE:
Neuroreport 1995 Oct 2;6(14):1853-6
NLM CIT. ID:
96107701
ABSTRACT:
Converging evidence points to hypofunction of the
left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS)
activates neurons near the surface of the brain. We questioned whether daily left
prefrontal rTMS might improve mood in depressed subjects and report a pilot study of such
treatment in six highly medication-resistant depressed inpatients. Depression scores
significantly improved for the group as a whole (Hamilton Depression Scores decreased from
23.8 +/- 4.2 (s.d.) at baseline to 17.5 +/- 8.4 after treatment; t = 3.03, 5DF, p = 0.02,
two-tailed paired t-test). Two subjects showed robust mood improvement which occurred
progressively over the course of several weeks. In one subject, depression symptoms
completely remitted for the first time in 3 years. Daily left prefrontal rTMS appears to
be safe, well tolerated and may alleviate depression.
Carbamazepine/THERAPEUTIC USE
Case Report
Case-Control Studies
Double-Blind Method
Female
Human
Magnetics
Middle Age
Pilot Projects
PUBLICATION TYPES:
JOURNAL ARTICLE
LANGUAGE:
Eng
REGISTRY NUMBERS:
298-46-4 (Carbamazepine)
On Sabbatical!
When my office
lease expired at the end of 2004, I decided to turn it into a
"sabbatical" from my private practice. Many years ago, in my
grandfather's 89th year of life, he told me, "John, it is important
to smell the roses while you can still smell them." His life
gave living a very good reputation. It is also true that the
pursuit of that philosophy required my grandfather to to re-open his
assay office/ore market in Wickenburg, Arizona as a 75-year-old because
he had run a little short of retirement money. Thus, if blessed with his
luck and health, I'll be back.. --jjh
