john herr psychologist los gatos saratoga california

On Sabbatical

National Library of Medicine: IGM Full Record Screen

Help Log off IGM
Next Record Return to Results Return to Search Screen Previous Record




TITLE: Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation.
AUTHOR: Walls EK; Phillips RJ; Wang FB; Holst MC; Powley TL
AUTHOR AFFILIATION: Purdue University, West Lafayette, Indiana 47907, USA.
SOURCE: Am J Physiol 1995 Dec;269(6 Pt 2):R1410-9
NLM CIT. ID: 96134769
ABSTRACT: The arrival of nutrients in the gastrointestinal tract suppresses intake. To specify the neural pathways and receptor locations of this feedback, we examined the effects of intraduodenal infusions of 10 nutrients plus saline on short-term food intake of rats with selective deafferentations of vagal celiac branches. Three response profiles were observed: 1) isotonic saline, 5.6% glycerol, and 3% fructose did not inhibit intake of controls or selectively deafferented animals; 2) 3% glucose, 3% maltose, 3% L-phenylalanine, 12% Isocal, and 1.4% oleic acid suppressed intake of controls, but this inhibition was eliminated by vagal celiac deafferentation; and 3) 3% casein hydrolysate and 24% Isocal suppressed intake of controls and rats with selective vagotomies, although the latter exhibited significantly less suppression. In addition, elimination of celiac afferents chronically reduced meal size (i.e., first 30-min intake) without reducing daily food intake or body weight. Furthermore, D-phenylalanine infusions produced a delayed suppression of food intake in controls (possibly from intraluminal irritation); however, this reduction was eliminated with celiac deafferentation. Overall, this experiment indicates that vagal celiac afferents are critical for preabsorptive detection of some energy-yielding molecules or properties of nutrient solutions (as well as, perhaps, intraluminal inflammation), but not others, which are still detected, although only partially.
MAIN MESH SUBJECTS: Celiac Plexus/*PHYSIOLOGY
*Eating/DRUG EFFECTS
*Enteral Nutrition
Vagus Nerve/*PHYSIOLOGY
ADDITIONAL MESH SUBJECTS: Afferent Pathways/PHYSIOLOGY
Animal
Body Weight
Denervation
Male
Phenylalanine/PHARMACOLOGY
Rats
Rats, Sprague-Dawley
Support, U.S. Gov't, P.H.S. Time Factors
Vagotomy
PUBLICATION TYPES: JOURNAL ARTICLE
LANGUAGE: Eng
REGISTRY NUMBERS: 3617-44-5 (Phenylalanine)

Help Log off IGM
Next Record Return to Results Return to Search Screen Previous Record


On Sabbatical!

When my office lease expired at the end of 2004, I decided to turn it into a "sabbatical" from my private practice. Many years ago, in my grandfather's 89th year of life, he told me, "John, it is important to smell the roses while you can still smell them." His life gave living a very good reputation. It is also true that the pursuit of that philosophy required my grandfather to to re-open his assay office/ore market in Wickenburg, Arizona as a 75-year-old because he had run a little short of retirement money. Thus, if blessed with his luck and health, I'll be back.. --jjh

Copyright 1998-2007  John J. Herr, Ph.D.                                   Please send comments to jjherr@clinicalpsychologist.com