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TITLE:
Suppression of meal size by intestinal nutrients
is eliminated by celiac vagal deafferentation.
AUTHOR:
Walls EK; Phillips RJ; Wang FB; Holst MC; Powley
TL
AUTHOR AFFILIATION:
Purdue University, West Lafayette, Indiana 47907,
USA.
SOURCE:
Am J Physiol 1995 Dec;269(6 Pt 2):R1410-9
NLM CIT. ID:
96134769
ABSTRACT:
The arrival of nutrients in the gastrointestinal
tract suppresses intake. To specify the neural pathways and receptor locations of this
feedback, we examined the effects of intraduodenal infusions of 10 nutrients plus saline
on short-term food intake of rats with selective deafferentations of vagal celiac
branches. Three response profiles were observed: 1) isotonic saline, 5.6% glycerol, and 3%
fructose did not inhibit intake of controls or selectively deafferented animals; 2) 3%
glucose, 3% maltose, 3% L-phenylalanine, 12% Isocal, and 1.4% oleic acid suppressed intake
of controls, but this inhibition was eliminated by vagal celiac deafferentation; and 3) 3%
casein hydrolysate and 24% Isocal suppressed intake of controls and rats with selective
vagotomies, although the latter exhibited significantly less suppression. In addition,
elimination of celiac afferents chronically reduced meal size (i.e., first 30-min intake)
without reducing daily food intake or body weight. Furthermore, D-phenylalanine infusions
produced a delayed suppression of food intake in controls (possibly from intraluminal
irritation); however, this reduction was eliminated with celiac deafferentation. Overall,
this experiment indicates that vagal celiac afferents are critical for preabsorptive
detection of some energy-yielding molecules or properties of nutrient solutions (as well
as, perhaps, intraluminal inflammation), but not others, which are still detected,
although only partially.
Afferent Pathways/PHYSIOLOGY
Animal
Body Weight
Denervation
Male
Phenylalanine/PHARMACOLOGY
Rats
Rats, Sprague-Dawley
Support, U.S. Gov't, P.H.S. Time Factors
Vagotomy
PUBLICATION TYPES:
JOURNAL ARTICLE
LANGUAGE:
Eng
REGISTRY NUMBERS:
3617-44-5 (Phenylalanine)
On Sabbatical!
When my office
lease expired at the end of 2004, I decided to turn it into a
"sabbatical" from my private practice. Many years ago, in my
grandfather's 89th year of life, he told me, "John, it is important
to smell the roses while you can still smell them." His life
gave living a very good reputation. It is also true that the
pursuit of that philosophy required my grandfather to to re-open his
assay office/ore market in Wickenburg, Arizona as a 75-year-old because
he had run a little short of retirement money. Thus, if blessed with his
luck and health, I'll be back.. --jjh
