National Library of Medicine: IGM
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TITLE:
Neuroregulation of the nose and bronchi.
AUTHOR:
Widdicombe JG
AUTHOR AFFILIATION:
Department of Physiology, St George's Hospital
Medical School, London, UK.
SOURCE:
Clin Exp Allergy 1996 May;26 Suppl 3:32-5
NLM CIT. ID:
96330665
ABSTRACT:
The vascular beds, submucosal glands, and airway
vasculature are the three primary effector tissues in the airways, and all are under the
control of the parasympathetic (vagal) and sympathetic nervous systems. Parasympathetic
nerves play a more important role in smooth muscle contraction and gland secretion. The
complex neurogenic mechanisms initiated by activation of sensory nerves have been
clarified to a large extent by studies on experimental animals. For example, inflammation
or an allergic response will cause neurogenic inflammation due to axon reflexes; central
nervous reflexes will modulate activity in all of the effector tissues; and these reflex
responses will be modulated by local reflexes via parasympathetic ganglia. Similar
mechanisms are suspected in humans, but their importance still needs to be fully
established.
MAIN MESH SUBJECTS:
Bronchi/*INNERVATION
Nervous System/*PHYSIOLOGY
*Nervous System Physiology
Nose/*INNERVATION
ADDITIONAL MESH SUBJECTS:
Animal
Human
Neurons, Afferent/PHYSIOLOGY
Parasympathetic Nervous System/PHYSIOLOGY
Sympathetic Nervous System/PHYSIOLOGY
PUBLICATION TYPES:
MEETING REPORT
REVIEW
REVIEW, TUTORIAL
LANGUAGE:
Eng
On Sabbatical!
When my office
lease expired at the end of 2004, I decided to turn it into a
"sabbatical" from my private practice. Many years ago, in my
grandfather's 89th year of life, he told me, "John, it is important
to smell the roses while you can still smell them." His life
gave living a very good reputation. It is also true that the
pursuit of that philosophy required my grandfather to to re-open his
assay office/ore market in Wickenburg, Arizona as a 75-year-old because
he had run a little short of retirement money. Thus, if blessed with his
luck and health, I'll be back.. --jjh
