TITLE:

Oral disopyramide in the treatment of recurrent neurocardiogenic syncope.

AUTHOR:

Bhaumick SK; Morgan S; Mondal BK

AUTHOR AFFILIATION:

Rotherham District General Hospital, S. Yorkshire, UK.

SOURCE:

Int J Clin Pract 1997 Jul-Aug;51(5):342

NLM CIT. ID:

98150361

ABSTRACT:

In neurocardiogenic syncope the normal compensatory response on assuming an upright posture is interrupted after several minutes and replaced by a paradoxical withdrawal of sympathetic activity and increased parasympathetic activity. The resulting reduction in blood pressure is severe, sympathetic activity is inhibited, plasma norepinephrine levels do not increase and the heart rate decreases. The defect is a paradoxical interruption of sympathetic excitation associated with parasympathetic excitation, causing profound vasodilatation and bradycardia. Disopyramide has been shown not only to treat the bradycardia but also to control the hypotension.

MAIN MESH SUBJECTS:

Anti-Arrhythmia Agents/*THERAPEUTIC USE
Disopyramide/*THERAPEUTIC USE
Syncope, Vasovagal/*DRUG THERAPY

ADDITIONAL MESH SUBJECTS:

Aged
Case Report
Female
Human
Recurrence

PUBLICATION TYPES:

JOURNAL ARTICLE

LANGUAGE:

Eng

REGISTRY NUMBERS:

0 (Anti-Arrhythmia Agents)
3737-09-5 (Disopyramide)

On Sabbatical!

When my office lease expired at the end of 2004, I decided to turn it into a "sabbatical" from my private practice. Many years ago, in my grandfather's 89th year of life, he told me, "John, it is important to smell the roses while you can still smell them." His life gave living a very good reputation. It is also true that the pursuit of that philosophy required my grandfather to to re-open his assay office/ore market in Wickenburg, Arizona as a 75-year-old because he had run a little short of retirement money. Thus, if blessed with his luck and health, I'll be back.. --jjh

On Sabbatical

On Sabbatical!

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