National Library of Medicine: IGM
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TITLE:
Mood disorders and menopause.
AUTHOR:
Pearlstein T; Rosen K; Stone AB
AUTHOR AFFILIATION:
Department of Psychiatry and Human Behavior,
Brown University School of Medicine, Providence, Rhode Island, USA.
SOURCE:
Endocrinol Metab Clin North Am 1997
Jun;26(2):279-94
NLM CIT. ID:
97337142
ABSTRACT:
Studies of depressive symptoms in menopausal
women indicate that menopause is not associated with increased rates of depression,
although mild mood and anxiety symptoms may occur in the few years prior to menopause.
Women with previous affective disorders that are cyclic or that are associated with
reproductive events may be at increased risk for depression at menopause. Because women
presenting to menopause clinics are more likely to have affective disorders, the efficacy
of estrogen for enhancing mood is an important question. Although some researchers suggest
that estrogens have proven mood-elevating and antidepressant properties, others caution
that the psychologic benefits of HRT deserve more systematic study before conclusions can
be made. It has been suggested that minor psychologic symptoms at menopause or psychologic
symptoms accompanied by vasomotor symptoms warrant a trial of HRT before considering
psychotropic medication. If the psychologic symptoms do not respond to HRT, are not
accompanied by vasomotor symptoms, or are clinically severe, antidepressant medication
should be considered first or in addition to HRT. The psychologic effects of progesterone
and androgens are less extensively studied than those of estrogen, and further research is
needed.
Androgens/PHYSIOLOGY/THERAPEUTIC USE
Clinical Trials
Depression/DRUG THERAPY/ETIOLOGY
Estrogen Replacement Therapy
Female
Human
Progesterone/THERAPEUTIC USE
Sex Behavior/DRUG EFFECTS
PUBLICATION TYPES:
JOURNAL ARTICLE
REVIEW
REVIEW, ACADEMIC
LANGUAGE:
Eng
REGISTRY NUMBERS:
0 (Androgens)
57-83-0 (Progesterone)
On Sabbatical!
When my office
lease expired at the end of 2004, I decided to turn it into a
"sabbatical" from my private practice. Many years ago, in my
grandfather's 89th year of life, he told me, "John, it is important
to smell the roses while you can still smell them." His life
gave living a very good reputation. It is also true that the
pursuit of that philosophy required my grandfather to to re-open his
assay office/ore market in Wickenburg, Arizona as a 75-year-old because
he had run a little short of retirement money. Thus, if blessed with his
luck and health, I'll be back.. --jjh
